Niopek News
Published: Phage-assisted evolution of allosteric protein switches
Phage-assisted evolution is a powerful tool for protein engineering, but what if a protein needs to be both highly active and tightly controllable?
Read all about how opposing selection pressures can be applied to evolve amazing protein switches here.
Article: https://www.nature.com/articles/s41467-026-71717-0
Bluesky: https://bsky.app/profile/neuroscinikolai.bsky.social/post/3mjjzy4zz322i
lab Retreat to Bad Herrenalb
March 2026
Published: Modular engineering of thermoresponsive allosteric proteins
We engineered proteins that act as temperature-sensitive switches, providing a blueprint for non-invasive control of gene editing and other cellular functions through, for example, focused ultrasound.
Article: https://www.nature.com/articles/s41592-025-02741-z
Bluesky: https://bsky.app/profile/jmathony.bsky.social/post/3menw6qnm6s2m
Published: Casandra
Controlling the controller just got an upgrade: we engineered broad-spectrum anti-CRISPR proteins with light- and drug-responsive domains, expanding the toolkit for precise spatiotemporal control of genome editing.
Article: https://academic.oup.com/nar/article/53/14/gkaf752/8222436
Bluesky: https://bsky.app/profile/niopeklab.bsky.social/post/3lbtwxlplp22r
Published: prodomino
Allosteric domains represent a powerful approach to control effector protein function, but where to insert them? If only we had a model to predict which sites are tolerated… oh wait!
Article: https://www.nature.com/articles/s41592-025-02741-z
Bluesky: https://bsky.app/profile/niopeklab.bsky.social/post/3lckftuf7qs2b
lab Lasertag
February 2025
2nd Lab Anniversary celebration
July 2025
Lab Hiking Trip
August 2024
First Lab Anniversary Celebration in Phantasialand
July 2024
